The USS Lowe was a Federation starship in Starfleet service in the 24th century.

Sara Nave's parents, both lieutenants, served aboard the Lowe in the early 2370s. In the year 2371, the Lowe was crippled while caught between combatants in an inter-planetary conflict. Nave was informed that her parents had been killed on the bridge of the Lowe. (TNG novel: Resistance)