During the brief Klingon-Romulan war in 2376, the Oregon was assigned to transport Ambassador Spock to a neutral location so that a peace could be negotiated between the two powers, so that they could lend assistance to the Federation as it faced a further Borg invasion. En route to the conference the Oregon was attacked by the Borg and was nearly destroyed. Thankfully, the USS Enterprise-E had travelled from an alternate future and managed to save the Oregon.
After destroying the Borg attackers, the Enterprise escorted the Oregon to the conference site to meet with Chancellor Martok and Admiral Sela. As a result the conference was a success and with Klingon and Romulan support Starfleet managed to defeat the Borg invasion of Sector 001. (TNG video game: Armada)