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The USS Perseverance was a Federation Starfleet starship in service in the 24th century.

In the early 2380s, Jefferson Blackmer served aboard the Perseverance for around two years. During this time, he became security chief and was promoted to lieutenant commander. In 2382, Blackmer transferred to Deep Space 9 and left the Perseverance. (ST - Typhon Pact novel: Plagues of Night, DS9 novel: Sacraments of Fire)