- For other uses, see Reliant.
Around 2327, in one of his first assignments after graduating Starfleet Academy, Ensign Jean-Luc Picard served on the Reliant, along with Lieutenant Mamoru Nakamura. (TNG episode: "The Measure of a Man")
- The scene was cut from the episode.
In 2369, Benjamin Sisko created a holoprogram that included the Reliant as part of an attempted strategy to defeat the Borg in a recreation of the Battle of Wolf 359. Sisko, theorizing new attack patterns he hoped might change the results of the battle, ordered the Reliant to concentrate weapons fire with three other starships to allow a boarding party to gain access to Locutus's cube. (DS9 comic: "Program 359")
- While the holoprogram mentioned the Reliant as present at the battle, it seems unlikely it could have been there, as the vessel survived to be mentioned again in later sources.