The USS Rhode Island (NCC-72701) was a Nova-class Federation starship in service in the early 25th century. She was commanded by Captain Harry Kim.
In 2409, the Rhode Island participated in a Starfleet raid on a Klingon starbase. (STO mission: "Fleet Alert")
In the same year, she was part of a Starfleet task force hiding from the Klingon Empire in the Kahless Expanse. (STO mission: "Empire Defense: Federation")
In an alternate timeline, the Rhode Island was sent on a four-year deep space mission in 2400. Four years later, the vessel intercepted Admiral Kathryn Janeway’s shuttle to stop her from going back in time. Captain Kim eventually decided to help Janeway complete her mission, and the Rhode Island helped defend Janeway's shuttle from Klingon warships. (VOY episode & novelization: Endgame)