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The USS Sanctuary was a Federation starship in service to Starfleet as a hospital ship in the mid-24th century. Doctor Beverly Crusher served aboard in the 2350s.

In the year 2357, the Sanctuary responded to a request for aid at the Starfleet outpost on Fradon II. The outpost had been attacked by Cardassian Union military forces leaving Starfleet and Cardassian wounded alike. Due to the sheer numbers of patients, the Sanctuary's captain ordered that all large enough available spaces, such as cargo bays and briefing rooms, be converted into triage stations. Doctor Crusher was directing operations and treating the injured in the ship's primary trauma center along with trauma nurse, Lieutenant Rahadyan Sastrowardoyo, and a young Bolian nurse. (ST - The Fall novel: Peaceable Kingdoms)

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