The USS Wounded Knee was a starship in service to Starfleet in the 24th century.

Lieutenant Commander Antigone Chen was assigned to the Wounded Knee sometime prior to 2380, and transferred off, to the USS Grace Hopper, on stardate 57809.

The Wounded Knee was assigned to the defense of Berengaria during the Borg Invasion of 2381, and was one of the vessels to come through that conflict unscathed. (TNG novel: Losing the Peace)