The USS Yukon was a Federation Starfleet personnel transport in service in the 23rd century. It possessed warp drive, was capable of making planetary landings and could operate with as few as three crewmembers.

In the year 2266, the Yukon departed Vanguard from docking bay 4 and transported Doctor Jabilo M'Benga, Lieutenant Commander T'Prynn and Tim Pennington to Vulcan in just under nine weeks. After landing at the main spaceport in Shi'Kahr, M'Benga, Pennington and T'Prynn were transported to the outskirts of Kren'than, while the Yukon's three-person crew reported to the Starfleet liaison office in the city. (VAN novel: Open Secrets)

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