Uthlow was a humanoid starship captain in the Delta Quadrant. In 2373, Uthlow and his crew were exploring the Tenebrous Cluster, where they encountered strange non-corporeal beings. Uthlow's crew called these creatures "Monthuglu," evil spirits of his culture's mythology. His entire crew was killed by Monthuglu, but he was spared when his ship moved into the empty "eye" of the cluster.

Uthlow was found unconscious on his ship by the USS Voyager on stardate 50719.8, and taken aboard that ship for medical treatment. Uthlow recovered and tried to warn Captain Janeway about the Monthuglu, but was met with skepticism.

As the Voyager was about to leave the Cluster, the creatures invaded the ship, and Uthlow was abducted from the bridge. (VOY - Strange New Worlds I short story: "Monthuglu")