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The Vatican City (Latin: Status Civitatis Vaticanae Italian: Stato della Città del Vaticano) was a landlocked sovereign enclave found within the city of Rome, Italy on Earth. Also known as, The Vatican, the city was the headquarters of the Pope - the leader of the Roman Catholic branch of Christianity on Earth.
As part of an effort to understand the religions of Earth, Doctor Phlox once visited the Vatican and attended Mass at St. Peter's Basilica prior to his service on board the Enterprise (NX-01). (ENT episode: "Cold Front")