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In 2163 D'Nesh ordered Doctor Honar-Des to commit Vyun-pashan after interrogating him over the theft of hormonal supplements that she and a number of other elite Orion women used to maintain their beauty and production of pheromones. Her sister Maras was unhappy to learn that D'Nesh had ordered her lifelong physician to commit suicide, but felt that after all his service he deserved a quick and painless end. (ENT - Rise of the Federation novel: Tower of Babel)
The Orion pirate captain was expected by his executive officer, Cophot, to have performed Vyun-pashan when captured by Captain James T. Kirk. He later attempted to swallow a poison pill. (TAS - Log Five novelization: The Pirates of Orion)