The Xawe were a humanoid amphibian species from the planet Xawen in either the Alpha or Beta Quadrant. At least one individual had mud-colored skin and half a dozen fleshy barbels at the corners of a wide lipless mouth, and it was hard to visually discern gender at first glance. They usually kept to themselves and did not engage in trade much, but when they did their ships were heavily laden with items to trade, making them targets for pirates. They had a couple of colonies along the border of Cardassian space. The Xawe had a monetary economy, which involves taxing inhabitants of colonies such as Anabasi, and their world was known for manufacturing computer equipment, which they treated as an art form. Negotiations for the Xawe to enter the United Federation of Planets were ongoing in the 2370s.

In 2371, the Xawe starship Gift of Flight was attacked by the Helios and destroyed. (DS9 novel: Proud Helios)