Zeta Alpha II was a location in the 24th century somewhere in the vicinity of Starbase 157, in the Zeta Alpha star system somewhere in the galaxy's Alpha or Beta Quadrants.

In the year 2366, the USS Lalo deparated from Zeta Alpha II bound for Sentinel Minor IV when it encountered a Borg cube and was destroyed. (TNG episode: "The Best of Both Worlds")

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