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Zodiac could refer to:
- Starships and vehicles:
- Zodiac-class, a class of warp shuttle used by Starfleet in the early 23rd century
- Zodiac-class, a starship class used by Starfleet in the late 24th century
- USS Zodiac, the lead ship of the Zodiac-class
- USS Zodiac, a Starfleet Constellation-class heavy destroyer in service in the 24th century
- USS Zodiac (NX-96100), a Starfleet Jupiter-class dreadnought in service in the early 25th century